Ontology highlight
ABSTRACT:
SUBMITTER: Rychahou P
PROVIDER: S-EPMC4613746 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Rychahou Piotr P Haque Farzin F Shu Yi Y Zaytseva Yekaterina Y Weiss Heidi L HL Lee Eun Y EY Mustain William W Valentino Joseph J Guo Peixuan P Evers B Mark BM
ACS nano 20150210 2
The majority of deaths from all cancers, including colorectal cancer (CRC), is a result of tumor metastasis to distant organs. To date, an effective and safe system capable of exclusively targeting metastatic cancers that have spread to distant organs or lymph nodes does not exist. Here, we constructed multifunctional RNA nanoparticles, derived from the three-way junction (3WJ) of bacteriophage phi29 motor pRNA, to target metastatic cancer cells in a clinically relevant mouse model of CRC metast ...[more]