Dataset Information

Arterial stiffness and ?-amyloid progression in nondemented elderly adults.

ABSTRACT: Recent studies show that cerebral ?-amyloid (A?) deposition is associated with blood pressure and measures of arterial stiffness in nondemented individuals.To examine the association between measures of arterial stiffness and change in A? deposition over time.Deposition of A? was determined in a longitudinal observational study of aging by positron emission tomography using the Pittsburgh compound B twice 2 years apart in 81 nondemented individuals 83 years and older. Arterial stiffness was measured with a noninvasive and automated waveform analyzer at the time closest to the second positron emission tomography scan. All measures were performed under standardized conditions. Pulse wave velocity (PWV) was measured in the central (carotid-femoral and heart-femoral PWV), peripheral (femoral-ankle PWV), and mixed (brachial-ankle PWV) vascular beds.The change in A? deposition over 2 years was calculated from the 81 individuals with repeat A?-positron emission tomography.The proportion of A?-positive individuals increased from 48% at baseline to 75% at follow-up. Brachial-ankle PWV was significantly higher among A?-positive participants at baseline and follow-up. Femoral-ankle PWV was only higher among A?-positive participants at follow-up. Measures of central stiffness and blood pressure were not associated with A? status at baseline or follow-up, but central stiffness was associated with a change in A? deposition over time. Each standard deviation increase in central stiffness (carotid-femoral PWV, P?=?.001; heart-femoral PWV, P?=?.004) was linked with increases in A? deposition over 2 years.This study showed that A? deposition increases with age in nondemented individuals and that arterial stiffness is strongly associated with the progressive deposition of A? in the brain, especially in this age group. The association between A? deposition changes over time and generalized arterial stiffness indicated a relationship between the severity of subclinical vascular disease and progressive cerebral A? deposition.

SUBMITTER: Hughes TM

PROVIDER: S-EPMC4267249 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Publications

Arterial stiffness and β-amyloid progression in nondemented elderly adults.

Hughes Timothy M TM Kuller Lewis H LH Barinas-Mitchell Emma J M EJ McDade Eric M EM Klunk William E WE Cohen Ann D AD Mathis Chester A CA Dekosky Steven T ST Price Julie C JC Lopez Oscar L OL

JAMA neurology 20140501 5

<h4>Importance</h4>Recent studies show that cerebral β-amyloid (Aβ) deposition is associated with blood pressure and measures of arterial stiffness in nondemented individuals.<h4>Objective</h4>To examine the association between measures of arterial stiffness and change in Aβ deposition over time.<h4>Design, setting, and participants</h4>Deposition of Aβ was determined in a longitudinal observational study of aging by positron emission tomography using the Pittsburgh compound B twice 2 years apar ...[more]

PMID: 24687165

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Project description:ImportanceLimited studies have investigated the association between statin use and progression of arterial stiffness, a key player in the pathophysiology of cardiovascular disease.ObjectiveTo examine the association between statin use and progression of arterial stiffness in Chinese adults with high atherosclerotic risk measured by brachial-ankle pulse wave velocity (baPWV).Design, setting, and participantsThis retrospective cohort study enrolled 5105 adults with high atherosclerotic risk from the Kailuan General Hospital from 2010 to 2020. Data were analyzed from February 2021 to April 2022.ExposuresStatin use information was retrieved from electronic medical records from 2010 to 2020, and statin users were those who have been prescribed any statin medications at least 6 months before baPWV measurements. Statin users were 1:1 matched with non-statin users by propensity score method.Main outcomes and measuresProgression of baPWV was assessed using the absolute difference between baseline and follow-up baPWV, divided by the follow-up time in years. Multivariable linear regression models were used to estimate the association between statin use and arterial stiffness.ResultsAmong 5105 adults with assessment of baPWV (mean [SD] age: 60.8 [9.7] years; 3842 [75.3%] men and 1263 [24.7%] women), 1310 statin users were matched with 1310 non-statin users (mean [SD] age, 63.2 [9.3] years). Compared with non-statin users, statin users were associated with significantly lower baPWV at baseline (difference: -33.6 cm/s; 95% CI, -62.1 to -5.1 cm/s). Among 1502 adults with repeated assessment of baPWV, 410 statin users were matched with 410 non-statin users (mean [SD] age, 62.9 [9.2] years). Compared with non-statin users, statin users had significantly slower progression of baPWV (difference, -23.3 cm/s per year; 95% CI, -40.6 to -6.0 cm/s per year) during a mean (SD) follow-up of 4.8 (2.7) years. A significantly slower progression of baPWV was observed in continuous statin users (difference, -24.2 cm/s per year; 95% CI, -42.2 to -6.3 cm/s per year) and high adherent users (difference, -39.7 cm/s per year; 95% CI, -66.9 to -12.4 cm/s per year), but not in discontinued users (difference, -17.3 cm/s per year; 95% CI, -52.4 to 17.8 cm/s per year) and low adherent users (difference, -17.9 cm/s per year; 95% CI, -36.5 to 0.7 cm/s per year), compared with non-statin users.Conclusions and relevanceIn this cohort study, statin use was associated with slower progression of arterial stiffness in Chinese adults with high atherosclerotic risk.

Dataset Information

Arterial stiffness and ?-amyloid progression in nondemented elderly adults.

Publications

Arterial stiffness and β-amyloid progression in nondemented elderly adults.

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