Dataset Information

Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly.

ABSTRACT: Hippocampal atrophy and abnormal ?-Amyloid (A?) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of A?-associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated A? correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderly, including global PET-A? in AD-vulnerable cortical regions and longitudinal subfield volumes quantified with a novel auto-segmentation method (FreeSurfer v.6.0). Moreover, we investigated associations of A?-related progressive subfield atrophy with memory decline. Across both datasets, we found a converging pattern that higher A? correlated with faster CA1 volume decline in NCI. This pattern spread to other hippocampal subfields in MCI group, correlating with memory decline. Our results for the first time suggest a longitudinal focal-to-widespread trajectory of A?-associated hippocampal subfield atrophy over disease progression in nondemented elderly.

SUBMITTER: Zhang L

PROVIDER: S-EPMC7267893 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly.

Zhang Liwen L Mak Elijah E Reilhac Anthonin A Shim Hee Y HY Ng Kwun K KK Ong Marcus Q W MQW Ji Fang F Chong Eddie J Y EJY Xu Xin X Wong Zi X ZX Stephenson Mary C MC Venketasubramanian Narayanaswamy N Tan Boon Y BY O'Brien John T JT Zhou Juan H JH Chen Christopher L H CLH

Human brain mapping 20200114 8

Hippocampal atrophy and abnormal β-Amyloid (Aβ) deposition are established markers of Alzheimer's disease (AD). Nonetheless, longitudinal trajectory of Aβ-associated hippocampal subfield atrophy prior to dementia remains unclear. We hypothesized that elevated Aβ correlated with longitudinal subfield atrophy selectively in no cognitive impairment (NCI), spreading to other subfields in mild cognitive impairment (MCI). We analyzed data from two independent longitudinal cohorts of nondemented elderl ...[more]

PMID: 31944479

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Project description:ImportanceRecent studies show that cerebral β-amyloid (Aβ) deposition is associated with blood pressure and measures of arterial stiffness in nondemented individuals.ObjectiveTo examine the association between measures of arterial stiffness and change in Aβ deposition over time.Design, setting, and participantsDeposition of Aβ was determined in a longitudinal observational study of aging by positron emission tomography using the Pittsburgh compound B twice 2 years apart in 81 nondemented individuals 83 years and older. Arterial stiffness was measured with a noninvasive and automated waveform analyzer at the time closest to the second positron emission tomography scan. All measures were performed under standardized conditions. Pulse wave velocity (PWV) was measured in the central (carotid-femoral and heart-femoral PWV), peripheral (femoral-ankle PWV), and mixed (brachial-ankle PWV) vascular beds.Main outcomes and measuresThe change in Aβ deposition over 2 years was calculated from the 81 individuals with repeat Aβ-positron emission tomography.ResultsThe proportion of Aβ-positive individuals increased from 48% at baseline to 75% at follow-up. Brachial-ankle PWV was significantly higher among Aβ-positive participants at baseline and follow-up. Femoral-ankle PWV was only higher among Aβ-positive participants at follow-up. Measures of central stiffness and blood pressure were not associated with Aβ status at baseline or follow-up, but central stiffness was associated with a change in Aβ deposition over time. Each standard deviation increase in central stiffness (carotid-femoral PWV, P = .001; heart-femoral PWV, P = .004) was linked with increases in Aβ deposition over 2 years.Conclusions and relevanceThis study showed that Aβ deposition increases with age in nondemented individuals and that arterial stiffness is strongly associated with the progressive deposition of Aβ in the brain, especially in this age group. The association between Aβ deposition changes over time and generalized arterial stiffness indicated a relationship between the severity of subclinical vascular disease and progressive cerebral Aβ deposition.

Dataset Information

Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly.

Publications

Longitudinal trajectory of Amyloid-related hippocampal subfield atrophy in nondemented elderly.

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