Ontology highlight
ABSTRACT:
SUBMITTER: Almaca J
PROVIDER: S-EPMC4267392 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Almaça Joana J Molina Judith J Arrojo E Drigo Rafael R Abdulreda Midhat H MH Jeon Won Bae WB Berggren Per-Olof PO Caicedo Alejandro A Nam Hong Gil HG
Proceedings of the National Academy of Sciences of the United States of America 20141117 49
Pancreatic islets secrete hormones that play a key role in regulating blood glucose levels (glycemia). Age-dependent impairment of islet function and concomitant dysregulation of glycemia are major health threats in aged populations. However, the major causes of the age-dependent decline of islet function are still disputed. Here we demonstrate that aging of pancreatic islets in mice and humans is notably associated with inflammation and fibrosis of islet blood vessels but does not affect glucos ...[more]