Ontology highlight
ABSTRACT:
SUBMITTER: Heikamp EB
PROVIDER: S-EPMC4267697 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Heikamp Emily B EB Patel Chirag H CH Collins Sam S Waickman Adam A Oh Min-Hee MH Sun Im-Hong IH Illei Peter P Sharma Archna A Naray-Fejes-Toth Aniko A Fejes-Toth Geza G Misra-Sen Jyoti J Horton Maureen R MR Powell Jonathan D JD
Nature immunology 20140406 5
SGK1 is an AGC kinase that regulates the expression of membrane sodium channels in renal tubular cells in a manner dependent on the metabolic checkpoint kinase complex mTORC2. We hypothesized that SGK1 might represent an additional mTORC2-dependent regulator of the differentiation and function of T cells. Here we found that after activation by mTORC2, SGK1 promoted T helper type 2 (TH2) differentiation by negatively regulating degradation of the transcription factor JunB mediated by the E3 ligas ...[more]