Ontology highlight
ABSTRACT:
SUBMITTER: Lee K
PROVIDER: S-EPMC2911434 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Lee Keunwook K Gudapati Prathyusha P Dragovic Srdjan S Spencer Charles C Joyce Sebastian S Killeen Nigel N Magnuson Mark A MA Boothby Mark M
Immunity 20100601 6
Many functions of the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) have been defined, but relatively little is known about the biology of an alternative mTOR complex, mTORC2. We showed that conditional deletion of rictor, an essential subunit of mTORC2, impaired differentiation into T helper 1 (Th1) and Th2 cells without diversion into FoxP3(+) status or substantial effect on Th17 cell differentiation. mTORC2 promoted phosphorylation of protein kinase B (PKB, or Akt) and PKC, Akt acti ...[more]