Ontology highlight
ABSTRACT:
SUBMITTER: Lin J
PROVIDER: S-EPMC4267722 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Nature communications 20141204
Cilia play essential roles in normal human development and health; cilia dysfunction results in diseases such as primary ciliary dyskinesia (PCD). Despite their importance, the native structure of human cilia is unknown, and structural defects in the cilia of patients are often undetectable or remain elusive because of heterogeneity. Here we develop an approach that enables visualization of human (patient) cilia at high-resolution using cryo-electron tomography of samples obtained noninvasively ...[more]