Ontology highlight
ABSTRACT:
SUBMITTER: Solomon GM
PROVIDER: S-EPMC5333960 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Solomon George M GM Francis Richard R Chu Kengyeh K KK Birket Susan E SE Gabriel George G Trombley John E JE Lemke Kristi L KL Klena Nikolai N Turner Brett B Tearney Guillermo J GJ Lo Cecilia W CW Rowe Steven M SM
JCI insight 20170309 5
Ciliary motion defects cause defective mucociliary transport (MCT) in primary ciliary dyskinesia (PCD). Current diagnostic tests do not assess how MCT is affected by perturbation of ciliary motion. In this study, we sought to use micro-optical coherence tomography (μOCT) to delineate the mechanistic basis of cilia motion defects of PCD genes by functional categorization of cilia motion. Tracheae from three PCD mouse models were analyzed using μOCT to characterize ciliary motion and measure MCT. ...[more]