Ontology highlight
ABSTRACT:
SUBMITTER: Wu BK
PROVIDER: S-EPMC4268240 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Wu Bo-Kuan BK Brenner Charles C
Cell reports 20141126 5
Hypermethylation-mediated tumor suppressor gene (TSG) silencing is a central epigenetic alteration in RAS-dependent tumorigenesis. Ten-eleven translocation (TET) enzymes can depress DNA methylation by hydroxylation of 5-methylcytosine (5mC) bases to 5-hydroxymethylcytosine (5hmC). Here, we report that suppression of TET1 is required for KRAS-induced DNA hypermethylation and cellular transformation. In distinct nonmalignant cell lines, oncogenic KRAS promotes transformation by inhibiting TET1 exp ...[more]