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Dilemmas in treating smoldering multiple myeloma.

ABSTRACT: Novel therapies hold promise for high-risk smoldering multiple myeloma (SMM). Recent studies suggest that modern combination approaches can be options for high-risk SMM to obtain deep molecular responses with favorable toxicity profiles. Although pioneering treatment trials based on small numbers of patients suggest progression-free and overall survival benefits, application of the data to real-life practice remains to be validated. Therapeutic modulation of disease tempo, disease burden, clonal evolution, and tumor microenvironment in SMM remains to be understood and calls for reliable biomarkers reflective of disease biology. Here, we review studies that open a new management platform for SMM, address ongoing dilemmas in practice and under investigation, and highlight emerging scientific questions in the era of SMM treatment.

SUBMITTER: Ahn IE

PROVIDER: S-EPMC4268248 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Dilemmas in treating smoldering multiple myeloma.

Ahn Inhye E IE Mailankody Sham S Korde Neha N Landgren Ola O

Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20141124 1

Novel therapies hold promise for high-risk smoldering multiple myeloma (SMM). Recent studies suggest that modern combination approaches can be options for high-risk SMM to obtain deep molecular responses with favorable toxicity profiles. Although pioneering treatment trials based on small numbers of patients suggest progression-free and overall survival benefits, application of the data to real-life practice remains to be validated. Therapeutic modulation of disease tempo, disease burden, clonal ...[more]

PMID: 25422486

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