Ontology highlight
ABSTRACT:
SUBMITTER: Bolli N
PROVIDER: S-EPMC6105687 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180822 1
We analyzed whole genomes of unique paired samples from smoldering multiple myeloma (SMM) patients progressing to multiple myeloma (MM). We report that the genomic landscape, including mutational profile and structural rearrangements at the smoldering stage is very similar to MM. Paired sample analysis shows two different patterns of progression: a "static progression model", where the subclonal architecture is retained as the disease progressed to MM suggesting that progression solely reflects ...[more]