Ontology highlight
ABSTRACT:
SUBMITTER: Park JW
PROVIDER: S-EPMC4268372 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Park Jung Wook JW Nickel Kwangok P KP Torres Alexandra D AD Lee Denis D Lambert Paul F PF Kimple Randall J RJ
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20140909 3
<h4>Background and purpose</h4>Patients with human papillomavirus related (HPV+) head and neck cancers (HNCs) demonstrate improved clinical outcomes compared to traditional HPV negative (HPV-) HNC patients. We have recently shown that HPV+ HNC cells are more sensitive to radiation than HPV- HNC cells. However, roles of HPV oncogenes in regulating the response of DNA damage repair remain unknown.<h4>Material and methods</h4>Using immortalized normal oral epithelial cell lines, HPV+ HNC derived ce ...[more]