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Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women.

ABSTRACT: Type 2 diabetes mellitus incidence is increased in HIV-infected persons. We examined the associations of diabetes mellitus with known diabetes mellitus-risk alleles from the general population in the context of HIV infection, and explored effect modification by combination antiretroviral therapy (cART).The Women's Interagency HIV Study is a prospective cohort of HIV-infected women. Seventeen European-derived diabetes mellitus-risk polymorphisms were genotyped in the eligible participants of the Women's Interagency HIV Study. Analyses were run separately for non-African Americans (Whites, Hispanics, Asians, and other; n?=?378, 49 with incident diabetes mellitus) and African Americans (n?=?591, 49 with incident diabetes mellitus). Cox proportional-hazards models were fit to estimate hazard ratios for diabetes mellitus overall and within strata of cART.In non-African Americans, heterogeneity across cART regimen was observed for nine of the 14 polymorphisms (phet?

SUBMITTER: Frasco MA 

PROVIDER: S-EPMC4269472 | biostudies-literature | 2014 Jul

REPOSITORIES: biostudies-literature

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Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women.

Frasco Melissa A MA   Karim Roksana R   Van Den Berg David D   Watanabe Richard M RM   Anastos Kathryn K   Cohen Mardge M   Gange Stephen J SJ   Gustafson Deborah R DR   Liu Chenglong C   Tien Phyllis C PC   Mack Wendy J WJ   Pearce Celeste L CL  

AIDS (London, England) 20140701 12

<h4>Objective</h4>Type 2 diabetes mellitus incidence is increased in HIV-infected persons. We examined the associations of diabetes mellitus with known diabetes mellitus-risk alleles from the general population in the context of HIV infection, and explored effect modification by combination antiretroviral therapy (cART).<h4>Methods</h4>The Women's Interagency HIV Study is a prospective cohort of HIV-infected women. Seventeen European-derived diabetes mellitus-risk polymorphisms were genotyped in  ...[more]

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