Ontology highlight
ABSTRACT:
SUBMITTER: Clayton GM
PROVIDER: S-EPMC4269484 | biostudies-literature | 2014 Jul
REPOSITORIES: biostudies-literature
Cell 20140701 1
T-cell-mediated hypersensitivity to metal cations is common in humans. How the T cell antigen receptor (TCR) recognizes these cations bound to a major histocompatibility complex (MHC) protein and self-peptide is unknown. Individuals carrying the MHCII allele, HLA-DP2, are at risk for chronic beryllium disease (CBD), a debilitating inflammatory lung condition caused by the reaction of CD4 T cells to inhaled beryllium. Here, we show that the T cell ligand is created when a Be(2+) cation becomes bu ...[more]