Ontology highlight
ABSTRACT:
SUBMITTER: Kowalczyk-Quintas C
PROVIDER: S-EPMC4269545 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Kowalczyk-Quintas Christine C Schuepbach-Mallepell Sonia S Willen Laure L Smith Terry K TK Huttner Kenneth K Kirby Neil N Headon Denis J DJ Schneider Pascal P
The Journal of investigative dermatology 20140910 2
Impaired ectodysplasin A (EDA) receptor (EDAR) signaling affects ectodermally derived structures including teeth, hair follicles, and cutaneous glands. The X-linked hypohidrotic ectodermal dysplasia (XLHED), resulting from EDA deficiency, can be rescued with lifelong benefits in animal models by stimulation of ectodermal appendage development with EDAR agonists. Treatments initiated later in the developmental period restore progressively fewer of the affected structures. It is unknown whether ED ...[more]