Ontology highlight
ABSTRACT:
SUBMITTER: Bellono NW
PROVIDER: S-EPMC4270065 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Bellono Nicholas W NW Escobar Iliana E IE Lefkovith Ariel J AJ Marks Michael S MS Oancea Elena E
eLife 20141216
Intracellular ion channels are essential regulators of organellar and cellular function, yet the molecular identity and physiological role of many of these channels remains elusive. In particular, no ion channel has been characterized in melanosomes, organelles that produce and store the major mammalian pigment melanin. Defects in melanosome function cause albinism, characterized by vision and pigmentation deficits, impaired retinal development, and increased susceptibility to skin and eye cance ...[more]