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Interleukin-17 inhibits adult hippocampal neurogenesis.

ABSTRACT: Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory synaptic transmission, enhanced intrinsic neuronal excitability, and increased expression of proneuronal genes in neuronal progenitor cells (NPCs). Our findings suggest a profound role of IL-17 in the negative regulation of adult hippocampal neurogenesis under physiology conditions.

SUBMITTER: Liu Q

PROVIDER: S-EPMC4271266 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Interleukin-17 inhibits adult hippocampal neurogenesis.

Liu Qiang Q Xin Wei W He Ping P Turner Dharshaun D Yin Junxiang J Gan Yan Y Shi Fu-Dong FD Wu Jie J

Scientific reports 20141219

Interleukin 17(A) (IL-17) is a potent pro-inflammatory cytokine that acts as a central regulator of inflammatory response within the brain, but its physiological roles under non-inflammatory conditions remain elusive. Here we report that endogenous IL-17 ablates neurogenesis in the adult dentate gyrus (DG) of hippocampus. Genetic deletion of IL-17 increased the number of adult-born neurons in the DG. Further, we found that IL-17 deletion altered cytokine network, facilitated basal excitatory syn ...[more]

PMID: 25523081

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