Altered sphingoid base profiles in type 1 compared to type 2 diabetes.
Ontology highlight
ABSTRACT: Background
Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) - an atypical class of sphingolipids in patients with metabolic syndrome (MetS) and diabetes type 2 (T2DM). It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated.Findings
We analyzed the long chain base profile by LC-MS after hydrolyzing the N-acyl and O-linked headgroups in plasma from individuals with T1DM (N?=?27), T2DM (N?=?30) and healthy controls (N?=?23). 1-deoxySLs were significantly higher in the groups with T2DM but not different between T1DM and controls. In contrast to patients with T2DM, 1-deoxSL levels are not elevated in T1DM.Conclusions
Our study indicates that the 1-deoxySL formation is not per-se caused by hyperglycemia but rather specifically associated with metabolic changes in T2DM, such as elevated triglyceride levels.
SUBMITTER: Wei N
PROVIDER: S-EPMC4271467 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Publications
Altered sphingoid base profiles in type 1 compared to type 2 diabetes.
Wei Nancy N Pan Jessica J Pop-Busui Rodica R Othman Alaa A Alecu Irina I Hornemann Thorsten T Eichler Florian S FS
Lipids in health and disease 20141011
<h4>Background</h4>Sphingolipids are increasingly recognized to play a role in insulin resistance and diabetes. Recently we reported significant elevations of 1-deoxysphingolipids (1-deoxySL) - an atypical class of sphingolipids in patients with metabolic syndrome (MetS) and diabetes type 2 (T2DM). It is unknown whether 1-deoxySL in patients with diabetes type 1 (T1DM) are similarly elevated.<h4>Findings</h4>We analyzed the long chain base profile by LC-MS after hydrolyzing the N-acyl and O-link ...[more]
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