Efficient prediction of human protein-protein interactions at a global scale.
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ABSTRACT:
SUBMITTER: Schoenrock A
PROVIDER: S-EPMC4272565 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Publications
Efficient prediction of human protein-protein interactions at a global scale.
Schoenrock Andrew A Samanfar Bahram B Pitre Sylvain S Hooshyar Mohsen M Jin Ke K Phillips Charles A CA Wang Hui H Phanse Sadhna S Omidi Katayoun K Gui Yuan Y Alamgir Md M Wong Alex A Barrenäs Fredrik F Babu Mohan M Benson Mikael M Langston Michael A MA Green James R JR Dehne Frank F Golshani Ashkan A
BMC bioinformatics 20141210
<h4>Background</h4>Our knowledge of global protein-protein interaction (PPI) networks in complex organisms such as humans is hindered by technical limitations of current methods.<h4>Results</h4>On the basis of short co-occurring polypeptide regions, we developed a tool called MP-PIPE capable of predicting a global human PPI network within 3 months. With a recall of 23% at a precision of 82.1%, we predicted 172,132 putative PPIs. We demonstrate the usefulness of these predictions through a range ...[more]
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