Ontology highlight
ABSTRACT:
SUBMITTER: van Leeuwen J
PROVIDER: S-EPMC5562937 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20161101 6312
Genetic suppression occurs when the phenotypic defects caused by a mutation in a particular gene are rescued by a mutation in a second gene. To explore the principles of genetic suppression, we examined both literature-curated and unbiased experimental data, involving systematic genetic mapping and whole-genome sequencing, to generate a large-scale suppression network among yeast genes. Most suppression pairs identified novel relationships among functionally related genes, providing new insights ...[more]