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Morita-Baylis-Hillman reaction of acrylamide with isatin derivatives.

ABSTRACT: The Morita-Baylis-Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in acetonitrile. The corresponding aza version with acrylate and acrylonitrile has also been developed resulting in high product yields.

SUBMITTER: Singh RM

PROVIDER: S-EPMC4273229 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Morita-Baylis-Hillman reaction of acrylamide with isatin derivatives.

Singh Radhey Mohan RM Bharadwaj Kishor Chandra KC Tiwari Dharmendra Kumar DK

Beilstein journal of organic chemistry 20141212

The Morita-Baylis-Hillman reaction of acrylamide, as an activated alkene, has seen little development due to its low reactivity. We have developed the reaction using isatin derivatives with acrylamide, DABCO as a promoter and phenol as an additive in acetonitrile. The corresponding aza version with acrylate and acrylonitrile has also been developed resulting in high product yields. ...[more]

PMID: 25550764

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