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Expedient Organocatalytic Aza-Morita-Baylis-Hillman Reaction through Ball-Milling.

ABSTRACT: A ball-milling enabled tertiary amine catalyzed aza-Morita-Baylis-Hillman reaction is reported. The reaction process does not require solvent, has significantly shorter reaction times than previous methods and is reported on a range of imines and acrylate Michael acceptors across than 26 examples. A 12-fold scaled-up example is also reported as well as experimental comparisons to solution-based experiments and neat-stirred reactions.

SUBMITTER: Williams MTJ

PROVIDER: S-EPMC7885690 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Expedient Organocatalytic Aza-Morita-Baylis-Hillman Reaction through Ball-Milling.

Williams Matthew T J MTJ Morrill Louis C LC Browne Duncan L DL

ACS sustainable chemistry & engineering 20201123 48

A ball-milling enabled tertiary amine catalyzed aza-Morita-Baylis-Hillman reaction is reported. The reaction process does not require solvent, has significantly shorter reaction times than previous methods and is reported on a range of imines and acrylate Michael acceptors across than 26 examples. A 12-fold scaled-up example is also reported as well as experimental comparisons to solution-based experiments and neat-stirred reactions. ...[more]

PMID: 33614300

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