Ontology highlight
ABSTRACT:
SUBMITTER: Gawad C
PROVIDER: S-EPMC4273416 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Gawad Charles C Koh Winston W Quake Stephen R SR
Proceedings of the National Academy of Sciences of the United States of America 20141125 50
Many cancers have substantial genomic heterogeneity within a given tumor, and to fully understand that diversity requires the ability to perform single cell analysis. We performed targeted sequencing of a panel of single nucleotide variants (SNVs), deletions, and IgH sequences in 1,479 single tumor cells from six acute lymphoblastic leukemia (ALL) patients. By accurately segregating groups of cooccurring mutations into distinct clonal populations, we identified codominant clones in the majority ...[more]