Ontology highlight
ABSTRACT:
SUBMITTER: Gao H
PROVIDER: S-EPMC4274615 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Gao H H Wu Y Y Zhang T T Wu Y Y Jiang L L Zhan J J Li J J Yang R R
Heredity 20140702 6
Given the drawbacks of implementing multivariate analysis for mapping multiple traits in genome-wide association study (GWAS), principal component analysis (PCA) has been widely used to generate independent 'super traits' from the original multivariate phenotypic traits for the univariate analysis. However, parameter estimates in this framework may not be the same as those from the joint analysis of all traits, leading to spurious linkage results. In this paper, we propose to perform the PCA for ...[more]