Ontology highlight
ABSTRACT:
SUBMITTER: Kluge SF
PROVIDER: S-EPMC4274627 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Kluge Silvia F SF Mack Katharina K Iyer Shilpa S SS Pujol François M FM Heigele Anke A Learn Gerald H GH Usmani Shariq M SM Sauter Daniel D Joas Simone S Hotter Dominik D Bibollet-Ruche Frederic F Plenderleith Lindsey J LJ Peeters Martine M Geyer Matthias M Sharp Paul M PM Fackler Oliver T OT Hahn Beatrice H BH Kirchhoff Frank F
Cell host & microbe 20141112 5
Most simian immunodeficiency viruses use their Nef protein to antagonize the host restriction factor tetherin. A deletion in human tetherin confers Nef resistance, representing a hurdle to successful zoonotic transmission. HIV-1 group M evolved to utilize the viral protein U (Vpu) to counteract tetherin. Although HIV-1 group O has spread epidemically in humans, it has not evolved a Vpu-based tetherin antagonism. Here we show that HIV-1 group O Nef targets a region adjacent to this deletion to in ...[more]