Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.
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ABSTRACT:
SUBMITTER: Sauter D
PROVIDER: S-EPMC2779047 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Publications
Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.
Sauter Daniel D Schindler Michael M Specht Anke A Landford Wilmina N WN Münch Jan J Kim Kyeong-Ae KA Votteler Jörg J Schubert Ulrich U Bibollet-Ruche Frederic F Keele Brandon F BF Takehisa Jun J Ogando Yudelca Y Ochsenbauer Christina C Kappes John C JC Ayouba Ahidjo A Peeters Martine M Learn Gerald H GH Shaw George G Sharp Paul M PM Bieniasz Paul P Hahn Beatrice H BH Hatziioannou Theodora T Kirchhoff Frank F
Cell host & microbe 20091101 5
Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize human tetherin to promote viral release and replication. We show that Vpus from SIVgsn, SIVmus, and SIVmon infecting Cercopithecus primate species also degrade CD4 and antagonize tetherin. In contrast, SIVcpz, the immediate precursor of HIV-1, whose Vpu shares a common ancestry with SIVgsn/mus/mon Vpu, uses Nef rather than Vpu to counteract chimpanzee tetherin. Human tetherin, however, is resistant to Nef and ...[more]
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