Ontology highlight
ABSTRACT:
SUBMITTER: Sauter D
PROVIDER: S-EPMC2779047 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Cell host & microbe 20091101 5
Vpu proteins of pandemic HIV-1 M strains degrade the viral receptor CD4 and antagonize human tetherin to promote viral release and replication. We show that Vpus from SIVgsn, SIVmus, and SIVmon infecting Cercopithecus primate species also degrade CD4 and antagonize tetherin. In contrast, SIVcpz, the immediate precursor of HIV-1, whose Vpu shares a common ancestry with SIVgsn/mus/mon Vpu, uses Nef rather than Vpu to counteract chimpanzee tetherin. Human tetherin, however, is resistant to Nef and ...[more]