Ontology highlight
ABSTRACT:
SUBMITTER: Watson GW
PROVIDER: S-EPMC4275561 | biostudies-literature | 2014 Dec
REPOSITORIES: biostudies-literature
Watson G W GW Wickramasekara S S Palomera-Sanchez Z Z Black C C Maier C S CS Williams D E DE Dashwood R H RH Ho E E
Oncogenesis 20141208
The isothiocyanate sulforaphane is a promising molecule for development as a therapeutic agent for patients with metastatic prostate cancer. Sulforaphane induces apoptosis in advanced prostate cancer cells, slows disease progression in vivo and is well tolerated at pharmacological doses. However, the underlying mechanism(s) responsible for cancer suppression remain to be fully elucidated. In this investigation we demonstrate that sulforaphane induces posttranslational modification of histone met ...[more]