Ontology highlight
ABSTRACT:
SUBMITTER: Van C
PROVIDER: S-EPMC4276476 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Van Christopher C Williams Jessica S JS Kunkel Thomas A TA Peterson Craig L CL
DNA repair 20141120
The yeast SWR-C chromatin remodeling enzyme catalyzes chromatin incorporation of the histone variant H2A.Z which plays roles in transcription, DNA repair, and chromosome segregation. Dynamic incorporation of H2A.Z by SWR-C also enhances the ability of exonuclease I (Exo1) to process DNA ends during repair of double strand breaks. Given that Exo1 also participates in DNA replication and mismatch repair, here we test whether SWR-C influences DNA replication fidelity. We find that inactivation of S ...[more]