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Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells.


ABSTRACT: Here, we sequenced the genome of the influenza A/Finland/741 M/2014(H1N1) virus and found that the virus accumulated oseltamivir resistance mutation H275Y in its neuraminidase during propagation in cell culture. This indicates that propagation in cell culture modifies virus genomes. The instability of influenza genomes should be taken into consideration during drug-sensitivity studies.

SUBMITTER: Mishel P 

PROVIDER: S-EPMC4276832 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Influenza pH1N1 Virus Accumulated H275Y Mutation in Neuraminidase during Propagation in MDCK Cells.

Mishel Polina P   Bychkov Dmitrii D   Kallio-Kokko Hannimari H   Valkonen Miia M   Kantele Anu A   Mattila Pirkko P   Almusa Henrikki H   Jalovaara Petri P   Kainov Denis D  

Genome announcements 20141224 6


Here, we sequenced the genome of the influenza A/Finland/741 M/2014(H1N1) virus and found that the virus accumulated oseltamivir resistance mutation H275Y in its neuraminidase during propagation in cell culture. This indicates that propagation in cell culture modifies virus genomes. The instability of influenza genomes should be taken into consideration during drug-sensitivity studies. ...[more]

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