Ontology highlight
ABSTRACT:
SUBMITTER: Krupka N
PROVIDER: S-EPMC4277125 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Drug design, development and therapy 20141217
Crohn's disease and ulcerative colitis are two chronic inflammatory bowel conditions. Current approved biologic therapies are limited to blocking tumor necrosis factor alpha. Unfortunately, some patients are primary nonresponders, experiencing a loss of response, intolerance, or side effects. This defines an unmet need for novel therapeutic strategies. The rapid recruitment and inappropriate retention of leukocytes is a hallmark of chronic inflammation and a potentially promising therapeutic tar ...[more]