The IL-33/ST2 pathway: therapeutic target and novel biomarker.
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ABSTRACT:
SUBMITTER: Kakkar R
PROVIDER: S-EPMC4277436 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Publications
The IL-33/ST2 pathway: therapeutic target and novel biomarker.
Kakkar Rahul R Lee Richard T RT
Nature reviews. Drug discovery 20081001 10
For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that was studied in the context of inflammatory and autoimmune disease. However, in 2005, a new cytokine--interleukin-33 (IL-33)--was identified as a functional ligand for ST2. IL-33/ST2 signalling is involved in T-cell mediated immune responses, but more recently, an unanticipated role in cardiovascular disease has been demonstrated. IL-33/ST2 not only represents a promising cardiovascular biomarker but also a n ...[more]
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