Ontology highlight
ABSTRACT:
SUBMITTER: Larsen KM
PROVIDER: S-EPMC6164146 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Larsen Kristen M KM Minaya Maydelis Karla MK Vaish Vivek V Peña Maria Marjorette O MMO
International journal of molecular sciences 20180909 9
Cancer is initiated by mutations in critical regulatory genes; however, its progression to malignancy is aided by non-neoplastic cells and molecules that create a permissive environment known as the tumor stroma or microenvironment (TME). Interleukin 33 (IL-33) is a dual function cytokine that also acts as a nuclear factor. IL-33 typically resides in the nucleus of the cells where it is expressed. However, upon tissue damage, necrosis, or injury, it is quickly released into extracellular space w ...[more]