Ontology highlight
ABSTRACT:
SUBMITTER: Chatterjee D
PROVIDER: S-EPMC4278046 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Chatterjee Debanjana D Marquardt Nicole N Tufa Dejene Milkessa DM Hatlapatka Tim T Hass Ralf R Kasper Cornelia C von Kaisenberg Constantin C Schmidt Reinhold Ernst RE Jacobs Roland R
Frontiers in immunology 20141229
Following allogeneic hematopoietic stem cell transplantation (HSCT), interferon (IFN)-γ levels in the recipient's body can strongly influence the clinical outcome. Human umbilical cord-derived mesenchymal stem cells (UC-MSCs) are lucrative as biological tolerance-inducers in HSCT settings. Hence, we studied the molecular mechanism of how UC-MSCs influence natural killer (NK) cell-mediated IFN-γ production. Allogeneic NK cells were cultured in direct contact with UC-MSCs or cell-free supernatants ...[more]