Ontology highlight
ABSTRACT:
SUBMITTER: Okamura K
PROVIDER: S-EPMC4278310 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Okamura Kyoko K Takayama Koichi K Kawahara Kohichi K Harada Taishi T Nishio Miki M Otsubo Kohei K Ijichi Kayo K Kohno Mikihiro M Iwama Eiji E Fujii Akiko A Ota Keiichi K Koga Takaomi T Okamoto Tatsuro T Suzuki Akira A Nakanishi Yoichi Y
Oncoscience 20140525 5
PICT1 is a key regulator of the MDM2-TP53 pathway. High mRNA expression levels of PICT1 are associated with poor prognosis in several cancers with wild-type TP53. In this study, we identified the PICT1 protein expression profile in non-small cell lung cancer (NSCLC) with wild-type TP53 in the nucleolus and cytoplasm, and revealed the relationship between PICT1 expression and patient clinicopathological factors. PICT1 expression in the tumor cells of 96 NSCLC patients with wild-type TP53 was eval ...[more]