Ontology highlight
ABSTRACT:
SUBMITTER: Zheng M
PROVIDER: S-EPMC7568706 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Cancer immunology, immunotherapy : CII 20200608 11
The cross-talk between cancer cells and monocyte-derived alveolar macrophages (Mo-AMs) promotes non-small cell lung carcinoma (NSCLC) progression. In this study, we report that both cancer cells and Mo-AMs robustly express beta 3-adrenergic receptor (ADRB3) in NSCLC. ADRB3 supports lung cancer cells proliferation and promotes chronic inflammation. Genetic and pharmacologic inhibition of ADRB3 reverses tumor growth and inflammation in mouse. Furthermore, we demonstrate that M5D1, a novel anti-ADR ...[more]