Ontology highlight
ABSTRACT:
SUBMITTER: Dave K
PROVIDER: S-EPMC4278765 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Dave Kaushalkumar K Averineni Ranjith R Sahdev Preety P Perumal Omathanu O
PloS one 20141229 12
The study was aimed at investigating localized topical drug delivery to the breast via mammary papilla (nipple). 5-fluorouracil (5-FU) and estradiol (EST) were used as model hydrophilic and hydrophobic compounds respectively. Porcine and human nipple were used for in-vitro penetration studies. The removal of keratin plug enhanced the drug transport through the nipple. The drug penetration was significantly higher through the nipple compared to breast skin. The drug's lipophilicity had a signific ...[more]