Ontology highlight
ABSTRACT:
SUBMITTER: Lindert S
PROVIDER: S-EPMC4278936 | biostudies-literature | 2015 Jan
REPOSITORIES: biostudies-literature
Lindert Steffen S Tallorin Lorillee L Nguyen Quynh G QG Burkart Michael D MD McCammon J Andrew JA
Journal of computer-aided molecular design 20141025 1
The need for novel therapeutics against Plasmodium falciparum is urgent due to recent emergence of multi-drug resistant malaria parasites. Since fatty acids are essential for both the liver and blood stages of the malarial parasite, targeting fatty acid biosynthesis is a promising strategy for combatting P. falciparum. We present a combined computational and experimental study to identify novel inhibitors of enoyl-acyl carrier protein reductase (PfENR) in the fatty acid biosynthesis pathway. A s ...[more]