Ontology highlight
ABSTRACT:
SUBMITTER: Dixit SR
PROVIDER: S-EPMC5676022 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Dixit Sheshagiri R SR Joshi Shrinivas D SD Kulkarni Venkatarao H VH Jalalpure Sunil S SS Kumbar Vijay M VM Mudaraddi Tulasigiriyappa Y TY Nadagouda Mallikarjuna N MN Aminabhavi Tejraj M TM
The open medicinal chemistry journal 20170926
<h4>Introduction</h4>In efforts to develop new antitubercular (anti-TB) compounds, herein we describe cytotoxic evaluation of 15 newly synthesized pyrrolyl pyrazoline carbaldehydes.<h4>Method & materials</h4>Surflex-Docking method was used to study binding modes of the compounds at the active site of the enzyme enoyl ACP reductase from <i>Mycobacterium tuberculosis (M. tuberculosis)</i>, which plays an important role in FAS-II biosynthetic pathway of <i>M. tuberculosis</i> and also it is an impo ...[more]