Ontology highlight
ABSTRACT:
SUBMITTER: Porru M
PROVIDER: S-EPMC4279385 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Porru Manuela M Zappavigna Silvia S Salzano Giuseppina G Luce Amalia A Stoppacciaro Antonella A Balestrieri Maria Luisa ML Artuso Simona S Lusa Sara S De Rosa Giuseppe G Leonetti Carlo C Caraglia Michele M
Oncotarget 20141101 21
Glioblastomas are highly aggressive adult brain tumors with poor clinical outcome. In the central nervous system (CNS) the blood-brain barrier (BBB) is the most important limiting factor for both development of new drugs and drug delivery. Here, we propose a new strategy to treat glioblastoma based on transferrin (Tf)-targeted self-assembled nanoparticles (NPs) incorporating zoledronic acid (ZOL) (NPs-ZOL-Tf). NPs-ZOL-Tf have been assessed on the glioblastoma cell line U373MG-LUC that showed a r ...[more]