Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC3577933 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Zhang Fan F Huang Xinglu X Zhu Lei L Guo Ning N Niu Gang G Swierczewska Magdalena M Lee Seulki S Xu Hong H Wang Andrew Y AY Mohamedali Khalid A KA Rosenblum Michael G MG Lu Guangming G Chen Xiaoyuan X
Biomaterials 20120503 21
Noninvasive imaging techniques have been considered important strategies in the clinic to monitor tumor early response to therapy. In the present study, we applied RGD peptides conjugated to iron oxide nanoparticles (IONP-RGD) as contrast agents in magnetic resonance imaging (MRI) to noninvasively monitor the response of a vascular disrupting agent VEGF(121)/rGel in an orthotopic glioblastoma model. RGD peptides were firstly coupled to IONPs coated with a crosslinked PEGylated amphiphilic triblo ...[more]