Ontology highlight
ABSTRACT:
SUBMITTER: Yang F
PROVIDER: S-EPMC4279415 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Yang Feng F Chen Yizhen Y Shen Tao T Guo Dan D Dakhova Olga O Ittmann Michael M MM Creighton Chad J CJ Zhang Yiqun Y Dang Truong D TD Rowley David R DR
Oncotarget 20141101 21
AR signaling is essential for the growth and survival of prostate cancer (PCa), including most of the lethal castration-resistant PCa (CRPC). We previously reported that TGF-β signaling in prostate stroma promotes prostate tumor angiogenesis and growth. By using a PCa/stroma co-culture model, here we show that stromal TGF-β signaling induces comprehensive morphology changes of PCa LNCaP cells. Furthermore, it induces AR activation in LNCaP cells in the absence of significant levels of androgen, ...[more]