Ontology highlight
ABSTRACT:
SUBMITTER: Jiang CY
PROVIDER: S-EPMC5864884 | biostudies-literature | 2018 Apr
REPOSITORIES: biostudies-literature
Jiang Chen-Yi CY Yang Bo-Yu BY Zhao Sheng S Shao Si-Hui SH Bei Xiao-Yu XY Shi Fei F Sun Qian Q Deng Zheng Z Wang Xiao-Hai XH Han Bang-Min BM Zhao Fu-Jun FJ Xia Shu-Jie SJ Ruan Yuan Y
Cell death & disease 20180401 4
The activation of androgen receptor (AR) signaling plays an essential role in both prostate stromal cells and epithelial cells during the development of benign prostatic hyperplasia (BPH). Here we demonstrated that androgen ablation after 5α-reductase inhibitor (5-ARI) treatment induced autophagy in prostate stromal fibroblasts inhibiting cell apoptosis. In addition, we found that ATG9A expression was increased after androgen ablation, which facilitated autophagic flux development. Knockdown of ...[more]