Unknown

Dataset Information

0

Deregulation of ATG9A by impaired AR signaling induces autophagy in prostate stromal fibroblasts and promotes BPH progression.


ABSTRACT: The activation of androgen receptor (AR) signaling plays an essential role in both prostate stromal cells and epithelial cells during the development of benign prostatic hyperplasia (BPH). Here we demonstrated that androgen ablation after 5?-reductase inhibitor (5-ARI) treatment induced autophagy in prostate stromal fibroblasts inhibiting cell apoptosis. In addition, we found that ATG9A expression was increased after androgen ablation, which facilitated autophagic flux development. Knockdown of ATG9A not only inhibited autophagy notably in prostate stromal fibroblasts, but also reduced the volumes of prostate stromal fibroblast and epithelial cell recombinant grafts in nude mice. In conclusion, our findings suggested that ATG9A upregulation after long-term 5-ARI treatment constitutes a possible mechanism of BPH progression. Thus, combined treatment with 5-ARI and autophagy inhibitory agents would reduce the risk of BPH progression.

SUBMITTER: Jiang CY 

PROVIDER: S-EPMC5864884 | biostudies-literature | 2018 Apr

REPOSITORIES: biostudies-literature

altmetric image

Publications

Deregulation of ATG9A by impaired AR signaling induces autophagy in prostate stromal fibroblasts and promotes BPH progression.

Jiang Chen-Yi CY   Yang Bo-Yu BY   Zhao Sheng S   Shao Si-Hui SH   Bei Xiao-Yu XY   Shi Fei F   Sun Qian Q   Deng Zheng Z   Wang Xiao-Hai XH   Han Bang-Min BM   Zhao Fu-Jun FJ   Xia Shu-Jie SJ   Ruan Yuan Y  

Cell death & disease 20180401 4


The activation of androgen receptor (AR) signaling plays an essential role in both prostate stromal cells and epithelial cells during the development of benign prostatic hyperplasia (BPH). Here we demonstrated that androgen ablation after 5α-reductase inhibitor (5-ARI) treatment induced autophagy in prostate stromal fibroblasts inhibiting cell apoptosis. In addition, we found that ATG9A expression was increased after androgen ablation, which facilitated autophagic flux development. Knockdown of  ...[more]

Similar Datasets

| S-EPMC4279415 | biostudies-literature
| S-EPMC6536403 | biostudies-literature
| S-EPMC3365773 | biostudies-literature
| S-EPMC9175887 | biostudies-literature
| S-EPMC8247603 | biostudies-literature
| S-EPMC6607583 | biostudies-literature
| S-EPMC3152578 | biostudies-literature
| S-EPMC4314374 | biostudies-literature
| S-EPMC5094946 | biostudies-literature
| S-EPMC3227636 | biostudies-literature