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Exercise, neurotrophins, and axon regeneration in the PNS.

ABSTRACT: Electrical stimulation and exercise are treatments to enhance recovery from peripheral nerve injuries. Brain-derived neurotrophic factor and androgen receptor signaling are requirements for the effectiveness of these treatments. Increased neuronal activity is adequate to promote regeneration in injured nerves, but the dosing of activity and its relationship to neurotrophins and sex steroid hormones is less clear. Translation of these therapies will require principles associated with their cellular mechanisms.

SUBMITTER: English AW

PROVIDER: S-EPMC4280152 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature

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Exercise, neurotrophins, and axon regeneration in the PNS.

English Arthur W AW Wilhelm Jennifer C JC Ward Patricia J PJ

Physiology (Bethesda, Md.) 20141101 6

Electrical stimulation and exercise are treatments to enhance recovery from peripheral nerve injuries. Brain-derived neurotrophic factor and androgen receptor signaling are requirements for the effectiveness of these treatments. Increased neuronal activity is adequate to promote regeneration in injured nerves, but the dosing of activity and its relationship to neurotrophins and sex steroid hormones is less clear. Translation of these therapies will require principles associated with their cellul ...[more]

PMID: 25362637

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