Ontology highlight
ABSTRACT:
SUBMITTER: Lorber B
PROVIDER: S-EPMC2770175 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Lorber Barbara B Howe Mariko L ML Benowitz Larry I LI Irwin Nina N
Nature neuroscience 20091025 11
Mammalian sterile 20-like kinase-3b (Mst3b, encoded by Stk24), regulates axon outgrowth in embryonic cortical neurons in culture, but its role in vivo and in neural repair is unknown. Here we show that Mst3b mediates the axon-promoting effects of trophic factors in mature rat retinal ganglion cells (RGCs) and dorsal root ganglion (DRG) neurons, and is essential for axon regeneration in vivo. Reducing Mst3b levels using short hairpin RNA prevented RGCs and DRG neurons from regenerating axons in r ...[more]