The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing.
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ABSTRACT:
SUBMITTER: Gaffen SL
PROVIDER: S-EPMC4281037 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Publications
The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing.
Gaffen Sarah L SL Jain Renu R Garg Abhishek V AV Cua Daniel J DJ
Nature reviews. Immunology 20140901 9
Following the discovery of T helper 17 (TH17) cells, the past decade has witnessed a major revision of the TH subset paradigm and substantial progress has been made in deciphering the molecular mechanisms of T cell lineage commitment and function. In this Review, we focus on the recent advances that have been made regarding the transcriptional control of TH17 cell plasticity and stability, as well as the effector functions of TH17 cells, and we highlight the mechanisms of IL-17 signalling in mes ...[more]
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