Membrane-spanning DNA nanopores with cytotoxic effect.
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ABSTRACT:
SUBMITTER: Burns JR
PROVIDER: S-EPMC4282124 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Publications
Membrane-spanning DNA nanopores with cytotoxic effect.
Burns Jonathan R JR Al-Juffali Noura N Janes Sam M SM Howorka Stefan S
Angewandte Chemie (International ed. in English) 20141007 46
DNA-based cytotoxic agents: Nanopores composed of folded DNA featuring a hydrophobic belt of ethyl phosphorothioate groups insert into bilayer membranes and kill cancer cells. The mode by which the pores achieve cell killing is elucidated with confocal microscopy. ...[more]
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