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Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?

ABSTRACT: Several studies suggest a role of oxidative stress in the physiopathology of migraine, particularly in the form with aura. In a case-control study, we investigated the association between migraine and superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) genes in a cohort of 490 consecutive unrelated Caucasian migraineurs (migraine with aura [MwA], n=107; migraine without aura [MwoA], n=246; chronic migraine [CM], n=137) and 246 healthy controls recruited at our Headache and Pain Unit and stored in the Interinstitutional Multidisciplinary BioBank (BioBIM). Migraine phenotype was carefully detailed using face-to-face interviews. We examined polymorphisms of SOD1 gene (A/C substitution-rs2234694) and SOD2 gene (C/T transition-rs4880-Ala16Val). The rs4880 TT (Val/Val) genotype was associated (p=0.042) with the presence of unilateral cranial autonomic symptoms (UAs) in MwA patients. We also found a mild correlation between SOD2 rs4880 genotype and the type of acute migraine treatment (p=0.048) in MwA patients. Our findings suggest that SOD2 is a disease-modifier gene influencing oxidative mechanisms in MwA. These observations lead to the hypothesis that SOD2 polymorphism may cause a defective control of the oxidative phenomena linked to cortical spreading depression, the neurophysiological hallmark of migraine aura, causing an overstimulation of trigeminal neurons and UAs triggering.

SUBMITTER: Palmirotta R

PROVIDER: S-EPMC4283069 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature

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Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?

Palmirotta Raffaele R Barbanti Piero P De Marchis Maria Laura ML Egeo Gabriella G Aurilia Cinzia C Fofi Luisa L Ialongo Cristiano C Valente Maria Giovanna MG Ferroni Patrizia P Della-Morte David D Guadagni Fiorella F

Antioxidants & redox signaling 20141111 3

Several studies suggest a role of oxidative stress in the physiopathology of migraine, particularly in the form with aura. In a case-control study, we investigated the association between migraine and superoxide dismutase 1 (SOD1) and superoxide dismutase 2 (SOD2) genes in a cohort of 490 consecutive unrelated Caucasian migraineurs (migraine with aura [MwA], n=107; migraine without aura [MwoA], n=246; chronic migraine [CM], n=137) and 246 healthy controls recruited at our Headache and Pain Unit ...[more]

PMID: 25295643

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Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?

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Is SOD2 Ala16Val polymorphism associated with migraine with aura phenotype?

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