Ontology highlight
ABSTRACT:
SUBMITTER: Bennett G
PROVIDER: S-EPMC4283503 | biostudies-literature | 2014 Jun
REPOSITORIES: biostudies-literature
Bennett Grace G Strissel Katherine J KJ DeFuria Jason J Wang Junpeng J Wu Dayong D Burkly Linda C LC Obin Martin S MS
Obesity (Silver Spring, Md.) 20140308 6
<h4>Objective</h4>To investigate the role of TNF-like weak inducer of apoptosis (TWEAK) in pathological adipose tissue (AT) remodeling and complications of obesity.<h4>Methods</h4>Wild type (WT) and TWEAK knockout (KO) mice were fed normal diet (ND) or a high fat diet (HFD) for up to 17 weeks. Adipocyte death was induced using an established transgenic mouse model of inducible adipocyte apoptosis (FAT-ATTAC). Metabolic, biochemical, histologic, and flow cytometric analyses were performed.<h4>Res ...[more]