Unknown

Dataset Information

0

Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Mugla province.


ABSTRACT: INTRODUCTION:Chronic obstructive pulmonary disease (COPD) is an irreversible progressive chronic inflammatory disease that causes shortness of breath in consequence of a decrease in pulmonary functions. The pulmonary inflammatory pathogenesis is multifactorial. We have too little up-to-date information about the relation between COPD and genetics. In our study, the relation with the SIRT1 gene's mononucleotide polymorphisms (SNP) rs7895833, rs7069102 and rs2273773 was analyzed through various laboratory data. MATERIAL AND METHODS:One hundred COPD patients from the archive records of the Chest Diseases Department of Mu?la Sitki Kocman University Medical Faculty were included in the study. A control group was constituted from 100 healthy individuals who live in the same geographical region. The SIRT1 genotypes for these patients were determined using polymerase chain reaction (PCR) and confronting two-pair primers (CTPP) methods. The SIRT1 gene polymorphisms rs7895833, rs7069102 and rs2273773 were analyzed. GG, AG, AA genotypes and G and A alleles of rs7895833, TT, TC, CC genotypes and T and C alleles of rs2273773, and CC, CG, GG genotypes and C and G alleles of rs7069102 were examined. The data in both groups were compared. CONCLUSIONS:A significant difference between GG, AG and AA genotypes of rs7895833 was found. Especially, the AG genotype was observed more in the group with COPD, with a significant difference. A significant difference between TT, TC and CC genotypes of rs2273773 was found. There was a significant difference between two groups with regards to C and G alleles of rs7069102. A significant difference was not found between the groups with regards to G and A alleles of rs7895833. A difference was not found for both groups between T and C alleles of rs2273773. It shows that these polymorphisms of the SIRT1 gene may be associated with COPD.

SUBMITTER: Kalemci S 

PROVIDER: S-EPMC4283875 | biostudies-literature | 2014 Sep

REPOSITORIES: biostudies-literature

altmetric image

Publications

Sirtuin gene polymorphisms are associated with chronic obstructive pulmonary disease in patients in Muğla province.

Kalemci Serdar S   Edgunlu Tuba Gokdogan TG   Kara Murat M   Turkcu Ummuhani Ozel UO   Cetin Esin Sakalli ES   Zeybek Arife A  

Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery 20140928 3


<h4>Introduction</h4>Chronic obstructive pulmonary disease (COPD) is an irreversible progressive chronic inflammatory disease that causes shortness of breath in consequence of a decrease in pulmonary functions. The pulmonary inflammatory pathogenesis is multifactorial. We have too little up-to-date information about the relation between COPD and genetics. In our study, the relation with the SIRT1 gene's mononucleotide polymorphisms (SNP) rs7895833, rs7069102 and rs2273773 was analyzed through va  ...[more]

Similar Datasets

| S-EPMC3464746 | biostudies-other
| S-EPMC3916114 | biostudies-literature
2016-05-25 | GSE77344 | GEO
| S-EPMC10067501 | biostudies-literature
| S-EPMC3816826 | biostudies-literature
| S-EPMC2775861 | biostudies-literature
2003-07-16 | GSE475 | GEO
| S-EPMC6687861 | biostudies-literature
2022-01-07 | PXD024124 | Pride
| S-EPMC3095932 | biostudies-literature