Ontology highlight
ABSTRACT:
SUBMITTER: Ayeni DO
PROVIDER: S-EPMC4283945 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Tetrahedron letters 20131101 45
A Julia-Kocienski approach to trifluoromethyl-substituted alkenes was evaluated in the reactions of 1,3-benzothiazol-2-yl, 1-phenyl-1<i>H</i>-tetrazol-5-yl, and 1-<i>t</i>butyl-1<i>H</i>-tetrazol-5-yl 2,2,2-trifluoroethyl sulfones with aldehydes. Among the various conditions tested, the best yields were obtained with 1-phenyl-1<i>H</i>-tetrazol-5-yl 2,2,2-trifluoroethyl sulfone, in CsF-mediated, room temperature olefinations in DMSO. Aromatic aldehydes gave (trifluoromethyl)vinyl derivatives in ...[more]